Mecp2tm1.1Mitoh
Targeted Allele Detail
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| Symbol: |
Mecp2tm1.1Mitoh |
| Name: |
methyl CpG binding protein 2; targeted mutation 1.1, Masayuki Itoh |
| MGI ID: |
MGI:5427621 |
| Synonyms: |
Xe2- |
| Gene: |
Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
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| Alliance: |
Mecp2tm1.1Mitoh page
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Placentas of embryos carrying a maternal Mecp2tm1.1Mitoh allele exhibit increased apoptosis
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:184364
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was replaced with a modified exon 2 containing the untranslated region (2x) fused to a tetracycline transactivator (2x-tTA), a loxP site, an FRT-flanked neo cassette, a tetracycline responsive promoter (TRE) fused to the coding sequence of exon 2 (2y; TRE-2y), and a loxP site. Cre-mediated recombination removed the neo cassette and TRE-2y.
(J:184364)
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Generation of the Mecp2tm1.1Mitoh allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mecp2 Mutation: |
38 strains or lines available
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| Original: |
J:184364 Itoh M, et al., Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development. J Biol Chem. 2012 Apr 20;287(17):13859-67 |
| All: |
1 reference(s) |
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Analysis Tools
