Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apoetm2(APOE_i3)Yhg
Name:	apolipoprotein E; targeted mutation 2, Yadong Huang
MGI ID:	MGI:5427462
Synonyms:	ApoE3-fKI, E3+
Gene:	Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance:	Apoetm2(APOE_i3)Yhg page

Germline Transmission:	Earliest citation of germline transmission: J:184138
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Apoetm2(APOE_i3)Yhg expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human APOE (348) Apoe  (MGI:88057) The APOE 3 isoform is expressed   Mutation details: The coding sequence (exons 2 through 4) was replaced with the corresponding human genomic sequence encoding isoform 3. A loxP site was inserted 5' of the human sequence and a neo cassette with a 5' loxP site was inserted downstream of the human sequence. (J:184138)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:	145 strains or lines available

Original:	J:184138 Bien-Ly N, et al., Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 4;32(14):4803-11
All:	6 reference(s)