Fcgr2btm1.1Rav
Targeted Allele Detail
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Symbol: |
Fcgr2btm1.1Rav |
Name: |
Fc receptor, IgG, low affinity IIb; targeted mutation 1.1, Jeffrey V Ravetch |
MGI ID: |
MGI:5426822 |
Synonyms: |
Fcgr2bfl |
Gene: |
Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
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Alliance: |
Fcgr2btm1.1Rav page
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Germline Transmission: |
Earliest citation of germline transmission:
J:183615
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of the exon encoding the first extracellular domain. A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain. Cre-mediated recombination removed the neo cassette.
(J:183615, J:209892)
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Generation of the Fcgr2btm1.1Rav allele |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fcgr2b Mutation: |
49 strains or lines available
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ES cells containing this allele were used to generate Fcgr3tm1Rav.
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Original: |
J:183615 Smith P, et al., Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6181-6 |
All: |
6 reference(s) |
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