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Fcgr2btm1.1Rav
Targeted Allele Detail
Summary
Symbol: Fcgr2btm1.1Rav
Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1.1, Jeffrey V Ravetch
MGI ID: MGI:5426822
Synonyms: Fcgr2bfl
Gene: Fcgr2b  Location: Chr1:170786186-170804116 bp, - strand  Genetic Position: Chr1, 78.02 cM
Alliance: Fcgr2btm1.1Rav page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183615
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the exon encoding the first extracellular domain. A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain. Cre-mediated recombination removed the neo cassette. (J:183615, J:209892)
Generation of the Fcgr2btm1.1Rav allele
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcgr2b Mutation:  49 strains or lines available
Notes
ES cells containing this allele were used to generate Fcgr3tm1Rav.
References
Original:  J:183615 Smith P, et al., Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6181-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory