Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Novartis Pharma AG
MGI ID:	MGI:5424000
Synonyms:	mR26-EF1alpha-EGFP
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa page

Germline Transmission:	Earliest citation of germline transmission: J:184312
Parent Cell Line:	BALB/c-I (ES Cell)
Strain of Origin:	BALB/cJ

Allele Type:    Targeted (RMCE-ready, Reporter) Mutation:    Insertion   Mutation details: Recombinase-mediated cassette exchange (RMCE) replaced the floxed hygro cassette in Gt(ROSA)26Sortm1Npa with an EEF1A1 promoter, EGFP and FRT-flanked neo cassette. EGFP is detected in all organs analyzed (salivary glands, heart, pancreas, liver, kidney, fat, muscle, brain and testis) and strong levels in testis. (J:184312)

Generation of the Gt(ROSA)26Sortm2(CAG-EGFP)Npa, Gt(ROSA)26Sortm3(CMV-EGFP)Npa, and Gt(ROSA)26Sortm4(EEF1A1-EGFP)Npa alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:184312 Tchorz JS, et al., A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS One. 2012;7(1):e30011
All:	1 reference(s)