Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Braftm1Tuv
Name:	Braf transforming gene; targeted mutation 1, David A Tuveson
MGI ID:	MGI:5318063
Synonyms:	LSL-B-RafV619E
Gene:	Braf  Location: Chr6:39580171-39702397 bp, - strand  Genetic Position: Chr6, 18.43 cM
Alliance:	Braftm1Tuv page

Germline Transmission:	Earliest citation of germline transmission: J:177503
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Single point mutation   Mutation details: A floxed STOP cassette blocks expression of a modified gene in which nucleotide substitution results in the amino acid substitution of glutamic acid for valine at position 619 (V619E). (J:177503)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:	58 strains or lines available

Original:	J:177503 Karreth FA, et al., In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma. Cell. 2011 Oct 14;147(2):382-95
All:	3 reference(s)