Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax6tm1.2Xzh
Name:	paired box 6; targeted mutation 1.2, Xin Zhang
MGI ID:	MGI:5317867
Synonyms:	Pax6deltaDP
Gene:	Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance:	Pax6tm1.2Xzh page

Germline Transmission:	Earliest citation of germline transmission: J:182769
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Hypomorph, Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Recombinase mediated recombination removed the neo cassette and a 3.1 kb region including the distal and the ectodermal enhancer elements. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5. (J:182769)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:	90 strains or lines available

Original:	J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
All:	1 reference(s)