Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akt1tm2Mbb
Name:	thymoma viral proto-oncogene 1; targeted mutation 2, Morris J Birnbaum
MGI ID:	MGI:5317852
Synonyms:	Akt1loxP
Gene:	Akt1  Location: Chr12:112620260-112641266 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
Alliance:	Akt1tm2Mbb page

Germline Transmission:	Earliest citation of germline transmission: J:182721
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 3, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 4 of the gene. (J:182721)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:	34 strains or lines available

Original:	J:182721 Wan M, et al., Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol. 2012 Jan;32(1):96-106
All:	2 reference(s)