Ror2tm1.1Meg
Targeted Allele Detail
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Symbol: |
Ror2tm1.1Meg |
Name: |
receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.1, Michael E Greenberg |
MGI ID: |
MGI:5315485 |
Synonyms: |
Ror2f |
Gene: |
Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
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Alliance: |
Ror2tm1.1Meg page
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Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg H2az2Tg(Wnt1-cre)11Rth/0 embryos exhibit sympathetic axon branching defects
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:182150
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A lox2272 site was inserted upstream of exon 3 and an FRT flanked neo cassette and lox2272 site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels.
(J:182150)
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Generation of Ror2tm1.1Meg and Ror2tm1.2Meg alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51 |
All: |
18 reference(s) |
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