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Lair1tm1Jco
Targeted Allele Detail
Summary
Symbol: Lair1tm1Jco
Name: leukocyte-associated Ig-like receptor 1; targeted mutation 1, John E Coligan
MGI ID: MGI:5308462
Synonyms: LAIR-1fl/fl
Gene: Lair1  Location: Chr7:4006401-4066178 bp, - strand  Genetic Position: Chr7, 2.31 cM
Alliance: Lair1tm1Jco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180203
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 4 followed by a frt-flanked neomycin resistance (neo) cassette and a second loxP site downstream of exon 8 via homologous recombination. Exons 4-8 contain two immunoreceptor tyrosine-based inhibition motifs (ITIM)that interact with the tyrosine phosphatases SHP1, SHP2 and SRC kinase. (J:180203)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lair1 Mutation:  35 strains or lines available
References
Original:  J:180203 Tang X, et al., Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. J Immunol. 2012 Jan 15;188(2):548-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory