Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tac2tm1.1(cre)Qima
Name:	tachykinin 2; targeted mutation 1.1, Qiufu Ma
MGI ID:	MGI:5307922
Synonyms:	Tac2-Cre
Gene:	Tac2  Location: Chr10:127560347-127567637 bp, + strand  Genetic Position: Chr10, 74.81 cM, cytoband D3
Alliance:	Tac2tm1.1(cre)Qima page

Germline Transmission:	Earliest citation of germline transmission: J:180805
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Tac2tm1.1(cre)Qima expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tac2 (MGI:98476)   Mutation details: The cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization. (J:180805)

Activity:	Tissue activity of this recombinase allele
Driver:	Tac2 (mouse) Summary of all recombinase alleles driven by Tac2. Alliance mouse Tac2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tac2 Mutation:	18 strains or lines available

Original:	J:180805 Mar L, et al., Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain. 2012;5:3
All:	7 reference(s)