Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc24a4tm1.1Hazh
Name:	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; targeted mutation 1.1, Haiqing Zhao
MGI ID:	MGI:5306364
Synonyms:	Nclx4-
Gene:	Slc24a4  Location: Chr12:102094992-102233350 bp, + strand  Genetic Position: Chr12, 51.42 cM
Alliance:	Slc24a4tm1.1Hazh page

Germline Transmission:	Earliest citation of germline transmission: J:180325
Parent Cell Line:	MC1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the olfactory bulb. (J:180325)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc24a4 Mutation:	34 strains or lines available

Original:	J:180325 Stephan AB, et al., The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci. 2012 Jan;15(1):131-7
All:	4 reference(s)