Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1.1Mvc
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Moses V Chao
MGI ID:	MGI:5306342
Synonyms:	GRflox
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1.1Mvc page

Germline Transmission:	Earliest citation of germline transmission: J:179918
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:179918)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:179918 Jeanneteau FD, et al., BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1305-10
All:	1 reference(s)