Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sirt1tm1.2Cxd
Name:	sirtuin 1; targeted mutation 1.2, Chu-Xia Deng
MGI ID:	MGI:5305225
Synonyms:	Sirt1flox5-6
Gene:	Sirt1  Location: Chr10:63154784-63174814 bp, - strand  Genetic Position: Chr10, 32.57 cM
Alliance:	Sirt1tm1.2Cxd page

Germline Transmission:	Earliest citation of germline transmission: J:179193
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette leaving exons 5 and 6 flanked by loxP sites. Liver specific deletion of the two floxed exons eliminates protein product in the liver. (J:140089, J:179193)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:	78 strains or lines available

Original:	J:179193 Wang RH, et al., Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6(7):682-90
All:	4 reference(s)