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Lmnb1tm1Yxz
Targeted Allele Detail
Summary
Symbol: Lmnb1tm1Yxz
Name: lamin B1; targeted mutation 1, Yixian Zheng
MGI ID: MGI:5301968
Gene: Lmnb1  Location: Chr18:56840885-56886496 bp, + strand  Genetic Position: Chr18, 30.84 cM
Alliance: Lmnb1tm1Yxz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178993
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 1.6-kb proximal promoter region and first exon were replaced by a loxP-flanked neomycin resistance cassette via homologous recombination. (J:178993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmnb1 Mutation:  38 strains or lines available
References
Original:  J:178993 Kim Y, et al., Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011 Dec 23;334(6063):1706-10
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory