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Il10tm2Hbo
Targeted Allele Detail
Summary
Symbol: Il10tm2Hbo
Name: interleukin 10; targeted mutation 2, Hicham Bouabe
MGI ID: MGI:5301908
Synonyms: ITIB
Gene: Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM
Alliance: Il10tm2Hbo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179239
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsTandem IRES2-beta-lactamase(TEM-1) genes were inserted immediately after the stop codon of exon 5. This was followed by a floxed neo selection cassette. The selection cassette was excised by crossing mice to Tg(CMV-cre)1Cgn mice. Fluorescence could be detected in both B cells and CD4+ T cells. (J:179239)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:  45 strains or lines available
References
Original:  J:179239 Bouabe H, et al., Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo. J Immunol. 2011 Sep 15;187(6):3165-76
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory