Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Cdkal1tm1.1Tomik Name: CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa MGI ID: MGI:5301441 Synonyms: Cdkal1flox Gene: Cdkal1  Location: Chr13:29375729-30039657 bp, - strand  Genetic Position: Chr13, 12.93 cM, cytoband A3.3 Alliance: Cdkal1tm1.1Tomik page

Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:178248
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:178248)

Generation of the Cdkal1tm1.1Tomik and Cdkal1tm1.2Tomik alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkal1 Mutation:	59 strains or lines available

Original:	J:178248 Wei FY, et al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608
All:	1 reference(s)