Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Juptm1.1Shou
Name:	junction plakoglobin; targeted mutation 1.1, Weinian Shou
MGI ID:	MGI:5296511
Synonyms:	Jupf
Gene:	Jup  Location: Chr11:100259784-100288589 bp, - strand  Genetic Position: Chr11, 63.47 cM
Alliance:	Juptm1.1Shou page

Germline Transmission:	Earliest citation of germline transmission: J:177567
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A neomycin selection cassette flanked by two loxP sites and a fragment including part of Jup introns 2-6 with a third loxP site inserted into intron 5 was engineered downstream of the neomycin selection cassette. The neomycin cassette was removed by breeding with Tg(EIIa-cre)C5379Lmgd mice, leaving exons 3-5 floxed (J:177567)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jup Mutation:	162 strains or lines available

Original:	J:177567 Li D, et al., Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
All:	3 reference(s)