Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fn1tm2.1Ref
Name:	fibronectin 1; targeted mutation 2.1, Reinhard Fassler
MGI ID:	MGI:5296500
Synonyms:	FNRGE
Gene:	Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance:	Fn1tm2.1Ref page

Germline Transmission:	Earliest citation of germline transmission: J:177821
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Single point mutation   Mutation details: A C1238G mutation in exon 30 results in an aspartic to glutamic acid change altering the RGD motif to RGE. A floxed neomycin resistance cassette was inserted in intron 30 and subsequently removed from properly targeted mice by cre excision. (J:177821)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:	129 strains or lines available

Original:	J:177821 Takahashi S, et al., The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007 Jul 2;178(1):167-78
All:	6 reference(s)