Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gata5tm1.1Nemr Name: GATA binding protein 5; targeted mutation 1.1, Mona Nemer MGI ID: MGI:5296251 Synonyms: Gata5fl Gene: Gata5  Location: Chr2:179966926-179976492 bp, - strand  Genetic Position: Chr2, 102.85 cM Alliance: Gata5tm1.1Nemr page

Bicuspid aortic valve in Gata5tm1.2Nemr/Gata5tm1.2Nemr Tg(Tek-cre)1Ywa/0 mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:175663
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 3 through 6 floxed. (J:175663)

Generation of the Gata5tm1.1Nemr and Gata5tm1.2Nemr alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata5 Mutation:	17 strains or lines available

Original:	J:175663 Laforest B, et al., Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011 Jul 1;121(7):2876-87
All:	2 reference(s)