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Slc13a5tm1.1Helf
Targeted Allele Detail
Summary
Symbol: Slc13a5tm1.1Helf
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5; targeted mutation 1.1, Stephen L Helfand
MGI ID: MGI:5293234
Synonyms: SLC13A5floxed
Gene: Slc13a5  Location: Chr11:72132815-72158048 bp, - strand  Genetic Position: Chr11, 43.95 cM
Alliance: Slc13a5tm1.1Helf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176732
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (129S/SvEv x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette, leaving exons 1 - 6 floxed. (J:176732)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc13a5 Mutation:  35 strains or lines available
Notes
D2 ES cells were used (J:176732)
References
Original:  J:176732 Birkenfeld AL, et al., Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 2011 Aug 3;14(2):184-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory