Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Selenoftm1Vgla Name: selenoprotein F; targeted mutation 1, Vadim N Gladyshev MGI ID: MGI:5293082 Gene: Selenof  Location: Chr3:144276188-144303438 bp, + strand  Genetic Position: Chr3, 68.94 cM, cytoband H3 Alliance: Selenoftm1Vgla page

Selenoftm1Vgla/Selenoftm1Vgla mice develop cataracts Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:176744
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neo cassette. The abscence of protein expression was confirmed by western blot analysis on mouse embryonic extracts. (J:176744)

Generation of the Selenoftm1Vgla allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Selenof Mutation:	21 strains or lines available

Original:	J:176744 Kasaikina MV, et al., Roles of the 15-kDa Selenoprotein (Sep15) in Redox Homeostasis and Cataract Development Revealed by the Analysis of Sep 15 Knockout Mice. J Biol Chem. 2011 Sep 23;286(38):33203-12
All:	4 reference(s)