Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrg1tm1Sabe
Name:	neuregulin 1; targeted mutation 1, Shin-ichi Abe
MGI ID:	MGI:5292107
Synonyms:	Nrg1loxP
Gene:	Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1tm1Sabe page

Germline Transmission:	Earliest citation of germline transmission: J:175448
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 6. A neo cassette with a 5' loxP site was inserted downstream of exon 6. (J:175448)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	53 strains or lines available

Original:	J:175448 Zhang J, et al., Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis. Development. 2011 Aug;138(15):3159-68
All:	4 reference(s)