Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1ctm4Hfm
Name:	calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 4, Franz Hofmann
MGI ID:	MGI:5291981
Synonyms:	Cav1.2I1624E
Gene:	Cacna1c  Location: Chr6:118564201-119173851 bp, - strand  Genetic Position: Chr6, 55.86 cM
Alliance:	Cacna1ctm4Hfm page

Germline Transmission:	Earliest citation of germline transmission: J:175463
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A floxed neo cassette was inserted upstream of a modified exon 40 in which nucleotide substitutions (ATC to GAG) results in the amino acid substitution of glutamic acid for isoleucine at position 1624 (I1624E). (J:175463)

Generation of the Cacna1ctm4Hfm allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:	141 strains or lines available

Original:	J:175463 Poomvanicha M, et al., Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif. J Biol Chem. 2011 Jul 29;286(30):26702-7
All:	2 reference(s)