Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax3tm6.1(Pax8)Buck
Name:	paired box 3; targeted mutation 6.1, Margaret E Buckingham
MGI ID:	MGI:5291822
Synonyms:	Pax3Pax8-ILZ, Pax3Pax8-IRES-nlacZ
Gene:	Pax3  Location: Chr1:78077904-78173771 bp, - strand  Genetic Position: Chr1, 39.79 cM
Alliance:	Pax3tm6.1(Pax8)Buck page

Germline Transmission:	Earliest citation of germline transmission: J:176192
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Cre-mediated recombination removed the EGFP and puro cassettes. The Pax8, IRES, and nuclear localized lacZ remain intact within intron 1. Expression of Pax3 is replaced with expression of Pax8. (J:176192)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax3 Mutation:	50 strains or lines available

Original:	J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
All:	1 reference(s)