Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2tm2.1Lbox
Name:	B cell leukemia/lymphoma 2; targeted mutation 2.1, Linda M Boxer
MGI ID:	MGI:5288478
Synonyms:	IgH-3'E-bcl2
Gene:	Bcl2  Location: Chr1:106465908-106642004 bp, - strand  Genetic Position: Chr1, 49.76 cM
Alliance:	Bcl2tm2.1Lbox page

Germline Transmission:	Earliest citation of germline transmission: J:175730
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The IgH 3' enhancer (normally located 170 kb from the promoter) with a floxed neo cassette was inserted downstream of the untranslated region. This insertion mimics the t(14;18) chromosomal translocation associated with human follicular B-cell lymphoma. Cre-mediated recombination removed the neo cassette. Protein expression is increased 3.5- to 5.5-fold. (J:175730)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:	41 strains or lines available

Original:	J:175730 Xiang H, et al., The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. Leukemia. 2011 Sep;25(9):1484-93
All:	1 reference(s)