Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Name:	serine peptidase inhibitor, Kazal type 5; transposon insertion 1498, Paul A Overbeek
MGI ID:	MGI:5286986
Synonyms:	OVE1498
Gene:	Spink5  Location: Chr18:44096302-44155568 bp, + strand  Genetic Position: Chr18, 23.74 cM
Alliance:	Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove page

Strain of Origin:

FVB/N

Allele Type:    Transposon induced Mutations:    Intergenic deletion, Transposon insertion   Mutation details: A transposon transgene containing mouse Pgk2 driving expression of sleeping beauty 10 (SB10) and a mouse tyrosinase minigene driven by a Tyr enhancer flanked by Sleeping Beauty inverted repeats (termed pT-Tybs-3'E) were co-injected with a Pgk2 driven SB10. In line 1498, transposon and transposase co-integration results in a 66.8 kb deletion containing the coding exons of the targeted gene and none of the coding regions of the genes flanking the integration site. RT-PCR confirmed the absence of transcript expression at P0 skin cDNA. (J:93050)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spink5 Mutation:	58 strains or lines available

Original:	J:93050 Yang T, et al., Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 1;18(19):2354-8
All:	1 reference(s)