Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lmnb2tm1.1Sgy
Name:	lamin B2; targeted mutation 1.1, Stephen G Young
MGI ID:	MGI:5285673
Synonyms:	Lmnb2fl
Gene:	Lmnb2  Location: Chr10:80737197-80754079 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance:	Lmnb2tm1.1Sgy page

Germline Transmission:	Earliest citation of germline transmission: J:174963
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked beta-geo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the reporter cassette. (J:174963)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lmnb2 Mutation:	27 strains or lines available

Original:	J:174963 Yang SH, et al., An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet. 2011 Sep 15;20(18):3537-44
All:	6 reference(s)