Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Mettm1Ics
Name:	met proto-oncogene; targeted mutation 1, Mouse Clinical Institute
MGI ID:	MGI:5285647
Synonyms:	MetLacZ
Gene:	Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Mettm1Ics page

Germline Transmission:	Earliest citation of germline transmission: J:174591
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Duplication, Insertion   Mettm1Ics involves 1 genes/genome features (Met) View all   Mutation details: A cassette containing a loxP site, duplicated exon 12, and a neo cassette with 3 polyadenylation sequences and a 3' loxP site was inserted upstream of exon 12. An IRES, nuclear localization sequence, and lacZ gene with a polyadenlylation sequence were inserted downstream of exon 12. (J:174591)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:	82 strains or lines available

Original:	J:174591 Lamballe F, et al., Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. 2011 Aug 3;31(31):11144-58
All:	2 reference(s)