Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Shank3tm1.1Bux
Name:	SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Joseph D Buxbaum
MGI ID:	MGI:5285391
Gene:	Shank3  Location: Chr15:89383826-89444464 bp, + strand  Genetic Position: Chr15, 44.96 cM
Alliance:	Shank3tm1.1Bux page

Germline Transmission:	Earliest citation of germline transmission: J:175320
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 9 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:175320)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shank3 Mutation:	77 strains or lines available

Original:	J:175320 Bozdagi O, et al., Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 2010;1(1):15
All:	3 reference(s)