Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stat1tm1Uvin
Name:	signal transducer and activator of transcription 1; targeted mutation 1, Uwe Vinkemeier
MGI ID:	MGI:5284857
Synonyms:	STAT1-deltaSUMO, STAT1-Glu705Gln
Gene:	Stat1  Location: Chr1:52158599-52201024 bp, + strand  Genetic Position: Chr1, 26.81 cM
Alliance:	Stat1tm1Uvin page

Germline Transmission:	Earliest citation of germline transmission: J:174863
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutation:    Nucleotide substitutions   Mutation details: Nucleotide substitution(s) results in the amino acid substitution of glutamine for glutamic acid at position 705 (E705Q) that abolishes SUMO conjugation. (J:174863)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:	72 strains or lines available

Original:	J:174863 Begitt A, et al., SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN{gamma}. Blood. 2011 Jul 28;118(4):1002-7
All:	1 reference(s)