About   Help   FAQ
Mdm2tm2.1Glo
Targeted Allele Detail
Summary
Symbol: Mdm2tm2.1Glo
Name: transformed mouse 3T3 cell double minute 2; targeted mutation 2.1, Guillermina Lozano
MGI ID: MGI:2385439
Synonyms: FM
Gene: Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance: Mdm2tm2.1Glo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75118
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe floxed neo cassette of Mdm2tm2Glo was excised from intron 6 via germline expression of cre recombinase. Exons 5 and 6, encoding most of the Trp53-binding domain (residues 53 through 113), were left flanked by single loxP sites in introns 4 and 6. (J:75118)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mdm2tm2.1Glo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:  54 strains or lines available
References
Original:  J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory