Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mdm2tm2Glo
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 2, Guillermina Lozano
MGI ID:	MGI:2385437
Synonyms:	FM-Neo
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm2Glo page

Germline Transmission:	Earliest citation of germline transmission: J:75118
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A construct, in which exons 5 and 6 were flanked by a loxP site in intron 4 and a floxed neo cassette in intron 6, was incorporated at the endogenous locus via homologous recombination. The floxed exons encode amino acids 53 through 113, which encompass most of the Trp53-binding domain. (J:75118)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
All:	2 reference(s)