Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scnn1atm1Hum
Name:	sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1, Edith Hummler
MGI ID:	MGI:2384526
Synonyms:	Scnn1aneo
Gene:	Scnn1a  Location: Chr6:125297622-125321906 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance:	Scnn1atm1Hum page

Germline Transmission:	Earliest citation of germline transmission: J:75110
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 1 of the gene was flanked by an upstream loxP site and a downstream floxed neo cassette. Northern blot and RT-PCR analysis showed reduced levels of transcript in mutant mice. (J:75110)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scnn1a Mutation:	27 strains or lines available

Original:	J:75110 Hummler E, et al., Conditional gene targeting of the Scnn1a (alphaENaC) gene locus. Genesis. 2002 Feb;32(2):169-72
All:	1 reference(s)