Mpztm1Msch
Targeted Allele Detail
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| Symbol: |
Mpztm1Msch |
| Name: |
myelin protein zero; targeted mutation 1, Melitta Schachner |
| MGI ID: |
MGI:2384133 |
| Synonyms: |
P0- |
| Gene: |
Mpz Location: Chr1:170978282-170988699 bp, + strand Genetic Position: Chr1, 79.05 cM
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| Alliance: |
Mpztm1Msch page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:3234
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| Parent Cell Line: |
AB1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 1 encoding the signal peptide was replaced with a neomycin resistance gene via homologous recombination. Southern blot analysis revealed several copies of the targeting vector had integrated as a concatemer in a head-to-tail manner. Western blot analysis of peripheral nerve proteins from homozygous mutant animals confirmed the absence of gene expression. The null allele was further verified by immunohistochemical analysis of femoral nerve sections from homozygous mutant animals using a polyclonal antibody to the protein. No immunoreactive staining was observed.
(J:3234)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mpz Mutation: |
28 strains or lines available
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| Original: |
J:3234 Giese KP, et al., Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell. 1992 Nov 13;71(4):565-76 |
| All: |
49 reference(s) |
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Analysis Tools
