Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plp1tm1Wst
Name:	proteolipid protein (myelin) 1; targeted mutation 1, Wilhelm Stoffel
MGI ID:	MGI:2384125
Synonyms:	plp-, plp/dm20/neo
Gene:	Plp1  Location: ChrX:135723420-135740482 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Alliance:	Plp1tm1Wst page

Germline Transmission:	Earliest citation of germline transmission: J:21976
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into intron 3 via homologous recombination to disrupt splicing of the gene product. Northern blot analysis confirmed the absence of normal transcripts in the brain of homozygous mutant animals. Western blot analysis and silver stained SDS-PAGE gels of myelin samples from homozygous mutants did not detect protein product of either isoform, PLP or DM20. (J:21976)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:	19 strains or lines available

Original:	J:21976 Boison D, et al., Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11709-13
All:	6 reference(s)