Pafah1b1tm1Awb
Targeted Allele Detail
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| Symbol: |
Pafah1b1tm1Awb |
| Name: |
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; targeted mutation 1, Anthony Wynshaw-Boris |
| MGI ID: |
MGI:2384054 |
| Synonyms: |
Lis1-, Lis-Neo, Pafah1b1ex6neo-8, Pafah1b1-neo |
| Gene: |
Pafah1b1 Location: Chr11:74564775-74615210 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B3
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| Alliance: |
Pafah1b1tm1Awb page
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Disruption of hippocampal layers in Lrp8tm1Her/Lrp8tm1Her, Pafah1b1tm1Awb/Pafah1b1+, and Lrp8tm1Her/Lrp8tm1Her Pafah1b1tm1Awb/Pafah1b1+ mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:49531
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: Part of exon 6 and all of exon 7 were replaced with a PGK-neo cassette in the opposite orientation via homologous recombination. The targeted mutation results in deletion of amino acids 164-214 and introduces multiple stop codons into exon 6. Homozygous mutant embryos were observed between E5.5 and E7.5 via Southern blot analysis.
(J:49531)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pafah1b1 Mutation: |
159 strains or lines available
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| Original: |
J:49531 Hirotsune S, et al., Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality [see comments]. Nat Genet. 1998 Aug;19(4):333-9 |
| All: |
37 reference(s) |
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Analysis Tools
