Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Fggtm1Fjc
Name:	fibrinogen gamma chain; targeted mutation 1, Francis J Castellino
MGI ID:	MGI:2384029
Synonyms:	FG-, Fib-
Gene:	Fgg  Location: Chr3:82915031-82922356 bp, + strand  Genetic Position: Chr3, 36.94 cM
Alliance:	Fggtm1Fjc page

Germline Transmission:	Earliest citation of germline transmission: J:64396
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette. Western blot analysis of blood plasma showed the absence of the gamma polypeptide, preventing the formation of the fibrinogen heterodimer in homozygous mutant mice. (J:64396)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Fggtm1Fjc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgg Mutation:	30 strains or lines available

Original:	J:64396 Ploplis VA, et al., A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol. 2000 Sep;157(3):703-8
All:	13 reference(s)