Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fcer1gtm1Tks
Name:	Fc receptor, IgE, high affinity I, gamma polypeptide; targeted mutation 1, Takashi Saito
MGI ID:	MGI:2384004
Synonyms:	Fcrg-, FcRgamma-, gamma-
Gene:	Fcer1g  Location: Chr1:171057141-171061918 bp, - strand  Genetic Position: Chr1, 79.23 cM
Alliance:	Fcer1gtm1Tks page

Germline Transmission:	Earliest citation of germline transmission: J:50023
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was deleted and replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot and RT-PCR analyses. The absence of the protein product of the endogenous locus was shown by FACS analysis of natural killer cells, macrophages, and neutrophils obtained from homozygous mutant mice. (J:50023)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fcer1g Mutation:	26 strains or lines available

Original:	J:50023 Park SY, et al., Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. J Clin Invest. 1998 Sep 15;102(6):1229-38
All:	52 reference(s)