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Tymptm1Akiy
Targeted Allele Detail
Summary
Symbol: Tymptm1Akiy
Name: thymidine phosphorylase; targeted mutation 1, Shin-ichi Akiyama
MGI ID: MGI:2183547
Synonyms: TP-
Gene: Tymp  Location: Chr15:89256134-89261242 bp, - strand  Genetic Position: Chr15, 44.86 cM, cytoband F1
Alliance: Tymptm1Akiy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78036
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons encoding the phosphate and deoxyribose binding domains were replaced with a neomycin selection cassette. Transcript was undetected via RT-PCR analysis total hepatic RNA. (J:78036)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tymp Mutation:  37 strains or lines available
References
Original:  J:78036 Haraguchi M, et al., Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol Cell Biol. 2002 Jul;22(14):5212-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory