Agttm1Ii
Targeted Allele Detail
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| Symbol: |
Agttm1Ii |
| Name: |
angiotensinogen; targeted mutation 1, Iekuni Ichikawa |
| MGI ID: |
MGI:2183545 |
| Synonyms: |
Agt-, Angt-KO |
| Gene: |
Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
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| Alliance: |
Agttm1Ii page
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Abnormal kidney morphology in 3 week old Agttm1Ii/Agttm1Ii mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:30061
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 1.5 kb region of the gene containing exon 2 was replaced with a PGK-neo cassette via homologous recombination. Exon 2 encodes the translation start site and the entire octapeptide region of the protein. Absence of gene expression was confirmed in homozygous mutant animals by Northern blot analysis of liver tissue. Furthermore, no plasma angiotensinogen could be detected in homozygous mutant animals.
(J:30061)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Agt Mutation: |
33 strains or lines available
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| Original: |
J:30061 Niimura F, et al., Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest. 1995 Dec;96(6):2947-54 |
| All: |
6 reference(s) |
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Analysis Tools
