Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ptentm1Mro Name: phosphatase and tensin homolog; targeted mutation 1, Silvia Marino MGI ID: MGI:2183284 Synonyms: Ptenfl, Ptenflox, Ptenfx, PtenLoxP Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM Alliance: Ptentm1Mro page

Prostate cancer progression in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+, Tg(Pbsn-cre)4Prb/0 Ptentm1Mro/Pten+, and Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ Ptentm1Mro/Pten+ mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:77123
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector which contained a floxed neomycin selection cassette in intron 4 and a loxP site in intron 5 was electroporated into ES cells that were subsequently transiently transfected with a cre recombinase expression plasmid. The expression of cre resulted in the excision of the neo transgene, leaving exon 5 flanked by loxP sites. Mice carrying this allele were used to generate Ptentm1.1. (J:77123)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptentm1Mro

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	81 strains or lines available

Original:	J:77123 Marino S, et al., PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development. 2002 Jul;129(14):3513-22
All:	40 reference(s)