Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra2tm1Uru
Name:	gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, Uwe Rudolph
MGI ID:	MGI:2183161
Synonyms:	alpha2(H101R), mutant allele 1
Gene:	Gabra2  Location: Chr5:71115735-71253192 bp, - strand  Genetic Position: Chr5, 37.59 cM
Alliance:	Gabra2tm1Uru page

Germline Transmission:	Earliest citation of germline transmission: J:65100
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Single point mutation   Mutation details: A point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 3 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra2tm1.1Uru. (J:65100)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra2 Mutation:	34 strains or lines available

Original:	J:65100 Low K, et al., Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000 Oct 6;290(5489):131-4
All:	5 reference(s)