Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Leprdb-NCSU
Name:	leptin receptor; diabetes, North Carolina State University
MGI ID:	MGI:2182820
Gene:	Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance:	Leprdb-NCSU page

Strain of Origin:

CD-1

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: Sequence analysis of the NCSU allele revealed a single nucleotide deletion in exon 12 . This deletion results in a shift of the reading frame, causing a substitution of 11 amino acids followed by a premature termination of the protein prior to the membrane spanning domain. (J:60363)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Original:	J:60363 Brown JA, et al., Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R320-30
All:	1 reference(s)