Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ets1tm1Jml
Name:	E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Jeffrey M Leiden
MGI ID:	MGI:2182789
Synonyms:	Ets-1-, Ets-1p
Gene:	Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Alliance:	Ets1tm1Jml page

Germline Transmission:	Earliest citation of germline transmission: J:77869
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Encoded protein was undetected via immunoblot analysis of protein extracts from homozygous mutant thymocytes. Subsequent western blot analysis has determined that 1% to 5% of endogenous levels of a protein lacking the Point domain is expressed. (J:77869, J:125056)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:	25 strains or lines available

Original:	J:77869 Muthusamy N, et al., Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 1995 Oct 19;377(6550):639-42
All:	8 reference(s)