Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ets1tm1Fwa
Name:	E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2182735
Synonyms:	Ets-1-, Ets-1d
Gene:	Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Alliance:	Ets1tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:29736
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 8 and 9, encoding the DNA-binding domain comprised of 110 carboxy terminal amino acids, were replaced by a PGK-neo cassette. An absence of transcript was determined in homozygous mutant mice via Northern blot analysis. (J:29736)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:	25 strains or lines available

Original:	J:29736 Bories JC, et al., Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995 Oct 19;377(6550):635-8
All:	7 reference(s)