Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Brca1tm2.1Cxd Name: breast cancer 1, early onset; targeted mutation 2.1, Chu-Xia Deng MGI ID: MGI:2182470 Synonyms: Brca1delta11, Brca1deltaexon11, Brcadelta11 Gene: Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D Alliance: Brca1tm2.1Cxd page

Exencephaly and growth retardation in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:70271
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele, lacking exon 11, was generated by crossing mice heterozygous for Brca1tm2Cxd with transgenic mice expressing the cre recombinase gene via the EIIa promoter which is active in germ cells. Northern blot analysis of homozygous mutant embryos indicated an absence of full length transcript. Transcript lacking exon 11 was detected in both wild-type and mutant embryos, though the levels were increased in homozygous mutant embyros. (J:70271)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	13 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Brca1tm2.1Cxd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:	113 strains or lines available

Original:	J:70271 Xu X, et al., Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71
All:	29 reference(s)