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Bace1tm1Slr
Targeted Allele Detail
Summary
Symbol: Bace1tm1Slr
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Steven L Roberds
MGI ID: MGI:2181643
Gene: Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance: Bace1tm1Slr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77414
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette, flanked by FLP recombinase target (FRT) sites was inserted into intron 3. An additional FRT site was inserted into intron 8, situating exons 4 through 8 in between FRT sites. Heterozygous mice were utilized to generate mice possessing Bacetm1.1Slr. (J:77414)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:  27 strains or lines available
References
Original:  J:77414 Roberds SL, et al., BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 1;10(12):1317-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory