Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(CAG-cre)Mnn
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jeffrey R Mann
MGI ID:	MGI:2181632
Synonyms:	Hprt1tm1(cre)Mnn, hprt-cre, Hprtcre, Hprttm1(CAG.cre)MdCoh
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(CAG-cre)Mnn page

Germline Transmission:	Earliest citation of germline transmission: J:75826
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Hprt1tm1(CAG-cre)Mnn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: An expression cassette in which a CMV enhancer and chicken beta-globin promoter driving Cre recombinase expression was inserted in reverse transcriptional orientation into exon 3 of the gene. A PGK-neomycin selection cassette was also inserted following the cre gene. Expression of Cre recombinase occurred at high levels in the female germline and fertilized eggs, and all offspring of heterozyous females display excision of reporter sequences. (J:75826)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

15 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:75826 Tang SH, et al., A cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis. 2002 Mar;32(3):199-202
All:	151 reference(s)