Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Rpe65tm1Tmr
Name:	retinal pigment epithelium 65; targeted mutation 1, T Michael Redmond
MGI ID:	MGI:2181399
Synonyms:	Rpe65-
Gene:	Rpe65  Location: Chr3:159304812-159330958 bp, + strand  Genetic Position: Chr3, 82.52 cM, cytoband H4
Alliance:	Rpe65tm1Tmr page

Germline Transmission:	Earliest citation of germline transmission: J:51293
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-3 of the gene were replaced with a PGK-neo cassette via homologous recombination. RT-PCR analysis of whole mouse eyes confirmed the null allele in homozygous mutant animals. (J:51293)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rpe65 Mutation:	47 strains or lines available

Original:	J:51293 Redmond TM, et al., Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998 Dec;20(4):344-51
All:	96 reference(s)