Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hnf1btm2Mya
Name:	HNF1 homeobox B; targeted mutation 2, Moshe Yaniv
MGI ID:	MGI:2181390
Synonyms:	Hnf1betadel, vHNF1/del
Gene:	Hnf1b  Location: Chr11:83741035-83796743 bp, + strand  Genetic Position: Chr11, 51.23 cM
Alliance:	Hnf1btm2Mya page

Germline Transmission:	Earliest citation of germline transmission: J:58080
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus via homologous recombination. Deletion of the promoter region, the transcription initiation site, and exon 1 was achieved by the transient expression of cre recombinase in ES cells. (J:58080)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:	16 strains or lines available

Original:	J:58080 Coffinier C, et al., Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development. 1999 Nov;126(21):4785-94
All:	3 reference(s)